Table 1.
Summary of secondary screen of TRAIL-induced caspase-3/7 activation
| Gene | MB231 (TNBC/Basal B) | MB468 (TNBC/Basal A) | T47D (ER+) | SKBR3 (HER2+) |
|---|---|---|---|---|
|
ACTN4 |
+ |
+ |
+ |
+ |
|
BCL2L1 |
+ |
+ |
+ |
(+) |
|
BIRC2 |
+ |
+ |
(+) |
+ |
|
ATP5A |
+ |
+ |
+ |
- |
|
BCR |
+ |
+ |
+ |
- |
|
FGFR4 |
+ |
+ |
(+) |
- |
|
PDPK1 |
+ |
+ |
(+) |
- |
|
PIP5K1C |
+ |
+ |
(+) |
- |
|
RIOK3 |
+ |
+ |
(+) |
- |
|
SRC |
+ |
+ |
(+) |
- |
|
CNKSR1 |
+ |
+ |
- |
- |
|
HIPK2 |
(+) |
+ |
- |
- |
|
MKNK1 |
(+) |
+ |
- |
- |
|
PLK3 |
+ |
+ |
- |
- |
|
PRKC1 |
+ |
+ |
- |
- |
| IKBKB | - | + | - | - |
+ indicates that three or more siRNAs for a target enhanced TRAIL-induced caspase-3/7 activity by >2 standard deviations (criterion 1).
(+) indicates three or more siRNAs for a target enhanced TRAIL-induced caspase-3/7 activity by >1 standard deviation (criterion 2).