Figure 4.

Hepatoprotective effect of BHE in CCl₄-intoxicated mice. (a) Group I (normal control): showing normal hepatic architecture and normal hepatocytes. (b) Group II (CCl₄-treated group): showing marked loss of hepatic architecture, marked hydropic degeneration, central vein congestion, and scattered lymphocytes in between the hepatocytes and in the sinusoids. (c and d) Groups III and IV (CCl₄ + 500 mg/kg or CCl₄ + 1000 mg/kg, respectively of BHE): showing preserved hepatic architecture. (e) Group V (CCl₄ + 500 mg/kg of silymarin): showing normal hepatic architecture and mild hydropic degeneration of hepatocytes (H & E, 200x). Hydropic degeneration (the black arrow), central vein congestion (the white arrow), and scattered lymphocytes in between the hepatocytes and in the sinusoids (the dotted black arrow).