Table 3.
Meta-analysis of the XPC polymorphisms and gastric cancer risk
|
Comparison |
Population |
No. of studies |
Test of association |
Mode |
Test of heterogeneity |
||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P Value | χ 2 | P Q Value | I 2 | ||||
| Lys939Gln |
|
|
|
|
|
|
|
|
|
| Gln/Gln vs. Lys/lys |
Overall |
5 |
1.123 |
0.881-1.431 |
0.349 |
F |
2.69 |
0.612 |
0.0 |
| |
Caucasian |
2 |
1.016 |
0.490-2.109 |
0.965 |
F |
2.31 |
0.128 |
46.8 |
| |
Asian |
3 |
1.140 |
0.857-1.516 |
0.368 |
F |
0.34 |
0.843 |
0.0 |
| |
PB |
2 |
1.260 |
0.877-1.810 |
0.212 |
F |
0.24 |
0.623 |
0.0 |
| |
HB |
3 |
1.026 |
0.741-1.420 |
0.879 |
F |
1.76 |
0.414 |
0.0 |
| |
High quality |
3 |
1.179 |
0.860-1.616 |
0.308 |
F |
0.75 |
0.686 |
0.0 |
| |
Low quality |
2 |
1.048 |
0.718-1.530 |
0.807 |
F |
1.71 |
0.191 |
41.6 |
| Gln/Lys vs. Lys/lys |
Overall |
5 |
1.083 |
0.917-1.277 |
0.347 |
F |
1.21 |
0.876 |
0.0 |
| |
Caucasian |
2 |
0.993 |
0.689-1.432 |
0.972 |
F |
0.87 |
0.352 |
0.0 |
| |
Asian |
3 |
1.107 |
0.919-1.332 |
0.284 |
F |
0.08 |
0.962 |
0.0 |
| |
PB |
2 |
1.026 |
0.795-1.324 |
0.846 |
F |
0.64 |
0.424 |
0.0 |
| |
HB |
3 |
1.126 |
0.906-1.400 |
0.285 |
F |
0.27 |
0.872 |
0.0 |
| |
High quality |
3 |
1.062 |
0.855-1.319 |
0.587 |
F |
0.90 |
0.639 |
0.0 |
| |
Low quality |
2 |
1.112 |
0.861-1.437 |
0.417 |
F |
0.24 |
0.628 |
0.0 |
| Gln/Gln + Gln/Lys vs. Lys/lys |
Overall |
5 |
1.092 |
0.933-1.277 |
0.273 |
F |
0.24 |
0.994 |
0.0 |
| |
Caucasian |
2 |
1.015 |
0.720-1.430 |
0.933 |
F |
0.01 |
0.906 |
0.0 |
| |
Asian |
3 |
1.113 |
0.933-1.327 |
0.235 |
F |
0.00 |
0.998 |
0.0 |
| |
PB |
2 |
1.076 |
0.846-1.369 |
0.551 |
F |
0.18 |
0.667 |
0.0 |
| |
HB |
3 |
1.103 |
0.897-1.356 |
0.351 |
F |
0.03 |
0.986 |
0.0 |
| |
High quality |
3 |
1.087 |
0.886-1.333 |
0.424 |
F |
0.21 |
0.900 |
0.0 |
| |
Low quality |
2 |
1.098 |
0.860-1.401 |
0.453 |
F |
0.02 |
0.881 |
0.0 |
| Gln/Gln vs. Gln/Lys + Lys/lys |
Overall |
5 |
1.046 |
0.838-1.307 |
0.691 |
F |
6.57 |
0.160 |
39.2 |
| |
Caucasian |
2 |
0.921 |
0.344-2.468 |
0.870 |
F |
5.98 |
0.114 |
43.3 |
| |
Asian |
3 |
1.083 |
0.829-1.417 |
0.558 |
F |
0.47 |
0.791 |
0.0 |
| |
PB |
2 |
1.253 |
0.896-1.751 |
0.187 |
F |
0.77 |
0.381 |
0.0 |
| |
HB |
3 |
0.914 |
0.680-1.229 |
0.552 |
F |
3.90 |
0.142 |
48.8 |
| |
High quality |
3 |
1.157 |
0.862-1.553 |
0.331 |
F |
1.66 |
0.435 |
0.0 |
| |
Low quality |
2 |
0.828 |
0.400-1.712 |
0.610 |
F |
3.90 |
0.148 |
44.3 |
| Ala499Val |
|
|
|
|
|
|
|
|
|
| Val/Val vs. Ala/Ala |
Asian |
3 |
0.861 |
0.632-1.172 |
0.341 |
F |
0.57 |
0.754 |
0.0 |
| Val/Ala vs. Ala/Ala |
Asian |
3 |
0.815 |
0.611-1.089 |
0.167 |
F |
4.72 |
0.194 |
37.6 |
| Val/Val + Val/Ala vs. Ala/Ala |
Asian |
3 |
0.823 |
0.630-1.076 |
0.155 |
F |
4.49 |
0.106 |
35.5 |
| Val/Val vs. Val/Ala + Ala/Ala |
Asian |
3 |
0.947 |
0.703-1.274 |
0.717 |
F |
0.04 |
0.981 |
0.0 |
| PAT−/+ |
|
|
|
|
|
|
|
|
|
| +/+vs. −/− |
Overall |
2 |
1.035 |
0.763-1.404 |
0.825 |
F |
0.12 |
0.726 |
0.0 |
| +/− vs. −/− |
Overall |
2 |
0.855 |
0.681-1.073 |
0.176 |
F |
0.00 |
0.975 |
0.0 |
| (+/+) + (+/−) vs. (−/−) |
Overall |
2 |
0.896 |
0.724-1.111 |
0.317 |
F |
0.05 |
0.830 |
0.0 |
| (+/+) vs. (+/−) + (−/−) | Overall | 2 | 1.141 | 0.871-1.495 | 0.338 | F | 0.20 | 0.652 | 0.0 |
OR, odds ratio; CI, confidence intervals; R, random effects model; F, fixed effects model; PB, Population–based; HB, Hospital–based.