Table 1. Distribution of risk factors in cases and rest of cohort.
| Characteristics | Rest of cohort | CRC cases | p | KRAS wild type | KRAS mutated | p | BRAF wild type | BRAF mutated | p |
| n (%) | 27514 | 584 | 314(63.6) | 180(36.4) | 423(85.6) | 71(14.4) | |||
| Sex (%) | <0.001 | 0.985 | 0.048 | ||||||
| male | 39.2 | 47.9 | 148(47.1) | 85(47.2) | 208(88.9) | 26(11.1) | |||
| female | 60.8 | 52.1 | 166(52.9) | 95(52.8) | 215(82.7) | 45(17.3) | |||
| Age at baseline (years) | |||||||||
| overall | 58.0 | 61.8 | <0.001 | 62.2 | 61.8 | 0.457 | 61.8 | 63.4 | 0.044 |
| male | 59.2 | 61.7 | <0.001 | 62.2 | 61.0 | 0.183 | 61.6 | 63.3 | 0.209 |
| female | 57.3 | 62.1 | <0.001 | 62.2 | 62.5 | 0.661 | 61.9 | 63.8 | 0.174 |
| Smoking (%) | 0.092 | 0.425 | 0.366 | ||||||
| regularly | 23.8 | 21.2 | 62(19.7) | 39(21.7) | 84(19.9) | 17(23.9) | |||
| occasionally | 4.5 | 3.4 | 7(2.2) | 7(3.8) | 14(3.3) | 0(0) | |||
| former smoker | 33.7 | 39.7 | 132(42.0) | 64(35.6) | 167(39.5) | 30(42.3) | |||
| never smoker | 37.9 | 35.6 | 113(36.0) | 70(38.9) | 158(37.4) | 24(33.8) | |||
| Smoking male (%) | 0.104 | 0.348 | 0.457 | ||||||
| regularly | 23.9 | 18.9 | 23(15.4) | 19(10.6) | 35(16.7) | 7(26.9) | |||
| occasionally | 4.8 | 4.3 | 3(2.0) | 4(2.2) | 7(3.3) | 0(0) | |||
| former smoker | 43.0 | 51.8 | 83(56.1) | 42(23.3) | 112(53.8) | 14(53.8) | |||
| never smoker | 28.2 | 25.0 | 39(26.2) | 20(11.1) | 54(25.7) | 5(19.2) | |||
| Smoking female (%) | 0.652 | 0.571 | 0.373 | ||||||
| regularly | 23.8 | 23.3 | 39(23.4) | 20(11.1) | 49(22.6) | 10(22.2) | |||
| occasionally | 4.3 | 2.6 | 4(2.4) | 3(1.7) | 7(3.2) | 0(0) | |||
| former smoker | 27.7 | 28.6 | 49(29.3) | 22(12.2) | 55(25.3) | 16(35.6) | |||
| never smoker | 44.2 | 45.4 | 74(44.6) | 50(27.8) | 104(48.4) | 19(42.2) | |||
| Level of education (%) | 0.023 | 0.429 | 0.409 | ||||||
| not completed | 0.8 | 0.9 | 3(1.0) | 1(0.6) | 2(0.4) | 2(2.8) | |||
| 6–8 years | 41.0 | 49.1 | 167(53.5) | 85(47.5) | 214(51.0) | 39(54.9) | |||
| 9–10 years | 26.2 | 22.4 | 71(22.8) | 37(20.7) | 93(22.1) | 15(21.1) | |||
| 10–12 years | 8.9 | 8.7 | 25(8.0) | 18(10.1) | 37(8.8) | 5(7.0) | |||
| 1 year university | 8.7 | 7.7 | 22(7.1) | 16(8.9) | 33(7.9) | 5(7.0) | |||
| university degree | 14.3 | 10.8 | 24(7.7) | 22(12.3) | 41(9.8) | 5(7.0) | |||
| Level of education male (%) | 0.912 | 0.793 | 0.042 | ||||||
| not completed | 0.8 | 0.7 | 1(0.7) | 0(0) | 0 | 1(3.8) | |||
| 6–8 years | 45.1 | 48.9 | 78(52.7) | 40(22.2) | 109(52.4) | 10(38.5) | |||
| 9–10 years | 19.6 | 19.6 | 30(20.1) | 16(8.9) | 42(20.2) | 4(15.4) | |||
| 10–12 years | 11.9 | 10.4 | 15(10.1) | 10(5.6) | 20(9.5) | 5(19.2) | |||
| 1 year university | 9.3 | 6.7 | 9(6.0) | 6(3.3) | 13(6.2) | 2(7.7) | |||
| university degree | 13.2 | 13.6 | 15(10.1) | 13(7.2) | 24(11.4) | 4(15.4) | |||
| Level of education female (%) | 0.009 | 0.688 | 0.167 | ||||||
| not completed | 0.8 | 1.0 | 2(1.2) | 1(0.6) | 2(0.9) | 1(2.2) | |||
| 6–8 years | 38.5 | 49.8 | 89(53.9) | 45(0.25) | 105(49.5) | 29(64.4) | |||
| 9–10 years | 30.5 | 24.9 | 41(24.8) | 21(11.7) | 51(23.8) | 11(24.4) | |||
| 10–12 years | 7.0 | 7.3 | 10(6.1) | 8(4.4) | 17(7.9) | 0(0) | |||
| 1 year university | 8.4 | 8.6 | 13(7.9) | 10(5.6) | 20(9.4) | 3(6.7) | |||
| university degree | 15.1 | 8.3 | 9(5.5) | 9(5.0) | 17(7.9) | 1(2.2) | |||
| Alcohol (g/day) | |||||||||
| overall | 10.7 | 10.8 | 0.404 | 10.4 | 11.2 | 0.286 | 11.2 | 7.8 | 0.052 |
| male | 15.5 | 15.7 | 0.793 | 16.3 | 15.6 | 0.925 | 16.3 | 14.2 | 0.842 |
| female | 7.7 | 6.2 | 0.001 | 5.1 | 7.3 | 0.134 | 6.3 | 4.0 | 0.112 |
| Height (cm) | |||||||||
| overall | 168.6 | 169.5 | 0.020 | 169.4 | 169.6 | 0.792 | 169.8 | 167.5 | 0.052 |
| male | 176.4 | 176.3 | 0.400 | 176.3 | 177.2 | 0.108 | 176.7 | 175.9 | 0.443 |
| female | 163.6 | 163.3 | 0.220 | 163.2 | 162.8 | 0.632 | 163.2 | 162.6 | 0.432 |
| Weight (kg) | |||||||||
| overall | 73.4 | 76.6 | <0.001 | 76.4 | 77.6 | 0.481 | 77.4 | 73.8 | 0.075 |
| male | 81.7 | 83.8 | 0.014 | 83.3 | 86.0 | 0.173 | 84.7 | 81.2 | 0.181 |
| female | 68.0 | 70.0 | 0.008 | 70.3 | 70.0 | 0.725 | 70.3 | 69.6 | 0.913 |
| Bodyfat % | |||||||||
| overall | 26.8 | 26.9 | 0.974 | 27.0 | 27.3 | 0.607 | 26.9 | 27.7 | 0.372 |
| male | 20.8 | 21.6 | 0.019 | 21.2 | 21.7 | 0.676 | 21.6 | 20.0 | 0.199 |
| female | 30.2 | 31.9 | <0.001 | 32.0 | 32.3 | 0.595 | 32.1 | 32.1 | 0.955 |
| Hip (cm) | |||||||||
| overall | 98.4 | 100.7 | <0.001 | 100.8 | 101.1 | 0.617 | 101.0 | 99.9 | 0.353 |
| male | 99.4 | 101.2 | <0.001 | 101.2 | 101.9 | 0.517 | 101.8 | 99.5 | 0.162 |
| female | 98.0 | 100.2 | <0.001 | 100.4 | 100.3 | 0.984 | 100.4 | 100.2 | 0.958 |
| Waist (cm) | |||||||||
| overall | 84.1 | 87.9 | <0.001 | 87.4 | 88.9 | 0.224 | 88.5 | 84.8 | 0.038 |
| male | 94.0 | 96.3 | <0.001 | 96.0 | 97.6 | 0.334 | 97.0 | 93.6 | 0.107 |
| female | 78.2 | 80.1 | 0.001 | 79.8 | 81.0 | 0.341 | 80.3 | 79.7 | 0.898 |
| WHR (cm/cm) | |||||||||
| overall | 0.85 | 0.87 | <0.001 | 0.87 | 0.88 | 0.184 | 0.87 | 0.85 | 0.036 |
| male | 0.94 | 0.95 | 0.021 | 0.95 | 0.96 | 0.323 | 0.95 | 0.94 | 0.349 |
| female | 0.80 | 0.80 | 0.525 | 0.79 | 0.81 | 0.062 | 0.80 | 0.80 | 0.808 |
| BMI (kg/m2) | |||||||||
| overall | 25.7 | 26.6 | <0.001 | 26.6 | 26.9 | 0.374 | 26.7 | 26.3 | 0.286 |
| male | 26.2 | 26.9 | <0.001 | 26.8 | 27.4 | 0.185 | 27.1 | 26.3 | 0.204 |
| female | 25.4 | 26.3 | 0.001 | 26.4 | 26.4 | 0.946 | 26.4 | 26.3 | 0.935 |