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. 2014 Jun 11;9(6):e99026. doi: 10.1371/journal.pone.0099026

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© 2014 Takahashi et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Monomeric IgA1 and its HR with nine possible sites of O-glycan attachment and the Fc portion of heavy chain with two N-glycans. Underlined serine (S) and threonine (T) residues in HR are frequently glycosylated [26], [30], [31]. Arrows show cleavage sites of trypsin and two IgA-specific proteases (from Clostridium ramosum AK183 and Haemophilus influenzae HK50). (B) O-glycan variants of circulatory IgA1∶1, Tn antigen; 2, sialyl-Tn antigen; 3, T antigen; 4, α3-sialyl-T antigen; 5, α6-sialyl-T antigen; 6, disialyl-T antigen. Abbreviations: GalNAc, N-acetylgalactosamine; Gal, galactose; NeuAc, N-acetylneuraminic acid.