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. 2014 Jun 11;9(6):e99114. doi: 10.1371/journal.pone.0099114

Table 3. Prevalence of low- and high-grade neoplasia of the larynx during the observation period, n (%) (N = 221).

Gender ≤SIN 1 SIN 2+Δ Total N (%)
Juvenile-onset RRP Male 28 (90.3) 3 (9.7) 31 (100)
Female 16 (88.9) 2 (11.1) 18 (100)
Adult-onset RRP* Male 107 (77.0) 32 (23.0) 139 (100)
Female 31 (93.9) 2 (6.1) 33 (100)

*The difference in development of SIN2+ was significant between genders in adults (p = 0.028).

Δ

High grade laryngeal neoplasia, including invasive SCC.