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. 2014 Jun 11;9(6):e98296. doi: 10.1371/journal.pone.0098296

Figure 3. D1 receptor agonist induced hyperresponsive locomotion in sensitized mice.

Figure 3

Locomotor activity (means + S.E.M.) of the saline, sens and nsens in the challenges with intra-NAc administration of saline and SKF-38393 at 0.1 or 1 µg/side. Each challenge was performed 48 h after the previous one. (A) Locomotor activity 20 min before and 60 min after saline intra-NAc administration of saline (n = 8), nsens (n = 5) and sens (n = 8) groups. (B) Locomotor activity 20 min before and 60 min after SKF 0.1 µg/side intra-NAc administration of saline (n = 8), nsens (n = 5) and sens (n = 8) groups, 48 h after the saline challenge (A). (C) Locomotor activity during 15 min (gray backgrounds in figures A and B), after intra-NAc administration of saline and SKF 0.1 µg/side. (D) Locomotor activity 20 min before and 60 min after saline intra-NAc administration of saline (n = 11), nsens (n = 6) and sens (n = 7) groups. (E) Locomotor activity 20 min before and 60 min after SKF 1 µg/side intra-NAc administration of saline (n = 11), nsens (n = 6) and sens (n = 7) groups, 48 h after the saline challenge (D). (F) Locomotor activity during 60 min (gray backgrounds in figures D and E), after intra-NAc administration of saline and SKF 1 µg/side. * indicates significantly higher activity levels than those of the saline and nsens mice and higher locomotor activity levels than their own levels in the saline challenge (p<0.05).