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. 2014 Jun 11;9(6):e100033. doi: 10.1371/journal.pone.0100033

Figure 1. TreeFam cladogram of HMG-CoA reductases.

Figure 1

The TreeFam family HMGCR (3-hydroxy-3-methylglutaryl-Coenzyme A reductase, TF105362) has 117 entries from 104 species. The final alignment was 1717 AA long and on average 56% conserved. TreeBest [9] was used to build a tree and reconcile it with the species tree. BLUE: N-terminal domain with HPIH motif found in fungi and with unknown function. GRAY: Sterol-sensing domain of SREBP cleavage-activation [26]. This domain is absent in C. elegans. RED: HMG-CoA reductase catalytic domain.