Figure 7. The atfs-1(et15) mutation suppresses hmgr-1(tm4368) mutant phenotypes when small amounts of mevalonate are provided.

Length (A–B), membrane localization of the prenylation reporter pGLO-1P::GFP-CAAX (C–D) and mitochondria structure (E–F) are significantly improved by the addition of 1 mM mevalonate in atfs-1(et15); hmgr-1(tm4368) double mutants than in hmgr-1(tm4368) single mutants. GFP-positive nuclei are labeled with “N”. *p<0.05 and ***p<0.001 using Student’s t-test.