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A, [Ca2+]i oscillations induced by prolonged application of caffeine (3 mM, 7 min). B, When 2-APB (100 µM) was co-applied, [Ca2+]i oscillations elicited by 3 mM caffeine was abolished. C, The average number of Ca2+ transients induced by caffeine (3 mM, 7 min) in the control group and the 2-APB group. * denotes statistical significance of p<0.05 with independent-samples t test.
