Table 2. QoL scale scores and differences between patient sub-groups by site of origin.
| QoL symptoms and functions | Prostate | Breast | Colorectal | Lung | Pancreatic | Others | ||||||||||||
| ND (527) | Rec (285) | Diff | ND (718) | Rec (1102) | Diff | ND (243) | Rec (628) | Diff | ND (730) | Rec (682) | Diff | ND (415) | Rec (292) | Diff | ND (1134) | Rec (1722) | Diff | |
| Global Health | 72·5 | 59·9 | 12·6(M) | 67·0 | 57·6 | 9·4(S) | 62·9 | 57·8 | 5·1(S) | 55·5 | 49·5 | 6·0(S) | 54·0 | 51·6 | 2·4 ** | 58·9 | 55·5 | 3·4 |
| Physical Function | 88·6 | 77·7 | 10·9(M) | 83·9 | 71·3 | 12·6(M) | 80·9 | 74·5 | 6·4(S) | 72·7 | 63·7 | 9·0(S) | 76·6 | 71·9 | 4·7 | 76·9 | 72·1 | 4·8 |
| Role Function | 86·1 | 72·5 | 13·6(M) | 76·4 | 64·6 | 11·8(M) | 68·5 | 66·6 | 1·9 ** | 61·1 | 54·6 | 6·5(S) | 59·8 | 58·7 | 1·1 ** | 64·7 | 62·7 | 2·0 * |
| Emotional Function | 76·3 | 71·0 | 5·3(S) | 64·5 | 65·6 | −1·1 ** | 68·7 | 67·6 | 1·1 ** | 62·1 | 63·6 | −1·5 ** | 62·6 | 66·3 | −3·7 * | 64·2 | 66·7 | −2·5 |
| Cognitive Function | 85·8 | 78·5 | 7·3 | 77·6 | 74·5 | 3·1 * | 81·1 | 77·8 | 3·3 ** | 76·1 | 72·8 | 3·3 * | 76·5 | 77·5 | −1·0 ** | 76·5 | 76·1 | 0·4 ** |
| Social Function | 84·5 | 72·0 | 12·5(M) | 73·7 | 63·6 | 10·1(M) | 70·1 | 65·0 | 5·1(S) * | 64·3 | 56·6 | 7·7(S) | 58·6 | 60·4 | −1·8 ** | 65·5 | 62·9 | 2·6 * |
| Fatigue | 23·0 | 35·5 | −12·5(M) | 33·1 | 45·0 | −11·9(M) | 38·1 | 43·8 | −5·7(S) * | 45·0 | 52·4 | −7·4(S) | 47·9 | 50·9 | −3·0 ** | 42·0 | 45·9 | −3·9 |
| Nausea/vomiting | 4·8 | 9·8 | −5·0(S) * | 8·4 | 14·7 | −6·3(S) | 11·5 | 14·4 | −2·9 * | 12·6 | 17·5 | −4·9 | 20·0 | 18·4 | 1·6 ** | 13·8 | 17·2 | −3·4 |
| Pain | 18·7 | 34·4 | −15·7(M) | 26·8 | 39·0 | −12·2(M) | 30·5 | 36·5 | −6·0(S) * | 36·2 | 42·4 | −6·2(S) | 44·6 | 41·6 | 3·0 ** | 34·7 | 37·2 | −2·5 * |
| Dyspnea | 12·3 | 17·9 | −5·6(S) | 15·3 | 26·2 | −10·9(M) | 18·2 | 22·7 | −4·5 ** | 37·1 | 41·7 | −4·6 * | 19·0 | 23·1 | −4·1 ** | 22·2 | 25·8 | −3·6 |
| Insomnia | 26·7 | 32·7 | −6·0(S) * | 37·4 | 40·0 | −2·6 ** | 37·9 | 38·4 | −0·5 ** | 42·2 | 40·6 | 1·6 ** | 41·2 | 38·5 | 2·7 ** | 39·5 | 38·4 | 1·1 ** |
| Appetite loss | 8·8 | 19·9 | −11·1(M) | 18·8 | 26·6 | −7·8(S) | 24·8 | 28·7 | −3·9 ** | 29·5 | 35·6 | −6·1(S) * | 43·5 | 35·4 | 8·1(S) | 28·7 | 30·2 | −1·5 ** |
| Constipation | 9·7 | 19·8 | −10·1(M) | 16·1 | 23·3 | −7·2(S) | 22·2 | 20·5 | 1·7 ** | 23·9 | 26·5 | −2·6 ** | 32·0 | 23·4 | 8·6(S) | 20·8 | 22·5 | −1·7 ** |
| Diarrhea | 7·3 | 9·5 | −2·2 ** | 11·0 | 11·0 | 0·0 ** | 16·9 | 16·9 | 0·0 ** | 9·2 | 10·5 | −1·3 ** | 15·2 | 17·7 | −2·5 ** | 11·6 | 14·9 | −3·3 |
| Financial | 18·4 | 24·8 | −6·4(S) * | 31·0 | 37·5 | −6·5(S) | 31·7 | 33·7 | −2·0 ** | 32·5 | 37·5 | −5·0(S) * | 33·6 | 29·3 | 4·3 ** | 33·0 | 35·7 | −2·7 * |
S, M, L Clinical relevance based on magnitude of point difference (Small:S [5]–[10]; Moderate:M [10]–[20]; Large:L [>20]) (supplementary color Table S10).
**Not Statistically Significant (p>0·05).
*Not Statistically Significant, multiple testing adjusted (p>0·0033).
ND/Rec Newly Diagnosed/Recurrent.
Diff Difference (ND-Rec).