Table 2. Mean LINE-1%5mC among controls.
| PLCO | ATBC | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | N | Mean LINE-1%5mC1 | (SE1) | P1,2 | Characteristic | N Controls | Mean LINE-1%5mC1 |
(SE1) | P1,2 |
| Gender | |||||||||
| Male | 560 | 84.2 | (0.09) | Male | 778 | 79.08 | (0.05) | ||
| Female | 116 | 83.5 | (0.19) | 0.0004 | Female | 0 | - | - | |
| Age at blood draw (years) | |||||||||
| - | 50–55 | 239 | 78.57 | (0.09) | |||||
| 55–59 | 84 | 84.5 | (0.23) | 55–59 | 250 | 78.99 | (0.09) | ||
| 60–64 | 169 | 83.9 | (0.17) | 60–64 | 197 | 79.59 | (0.10) | ||
| 65–69 | 213 | 83.6 | (0.16) | 65–70 | 92 | 79.53 | (0.14) | <0.001 | |
| 70–79 | 210 | 83.8 | (0.16) | 0.01 | - | ||||
| Years between age at blood draw and case diagnosis/control selection | |||||||||
| ≤1 | 149 | 84.1 | (0.18) | ≤1 | 95 | 79.11 | (0.14) | ||
| 2–3 | 190 | 83.9 | (0.16) | 2–3 | 92 | 78.96 | (0.14) | ||
| 4–6 | 182 | 83.8 | (0.17) | 4–6 | 133 | 78.88 | (0.12) | ||
| 7–13 | 155 | 83.6 | (0.18) | 0.02 | 7–13 | 383 | 78.94 | (0.07) | |
| - | 14–16 | 75 | 80.22 | (0.15) | 0.01 | ||||
| Center | |||||||||
| Colorado | 55 | 84.4 | (0.29) | Kouvola | 35 | 79.77 | (0.23) | ||
| Georgetown | 40 | 84.4 | (0.33) | Kotka | 35 | 79.06 | (0.23) | ||
| Henry Ford | 57 | 84.1 | (0.28) | Helsinki | 220 | 78.95 | (0.09) | ||
| Minnesota | 184 | 83.5 | (0.17) | Jyvaskyla | 65 | 79.47 | (0.17) | ||
| Washington | 60 | 84.0 | (0.27) | Hameenlinna | 43 | 78.84 | (0.21) | ||
| Pittsburgh | 102 | 83.8 | (0.21) | Lahti | 36 | 79.44 | (0.23) | ||
| Utah | 70 | 83.6 | (0.25) | Meltola | 13 | 78.90 | (0.39) | ||
| Marshfield | 96 | 83.9 | (0.22) | Pori | 44 | 79.43 | (0.21) | ||
| Alabama | 12 | 83.8 | (0.60) | 0.13 | Tampere | 77 | 79.16 | (0.16) | |
| Salo | 17 | 79.19 | (0.33) | ||||||
| Seinajoki | 68 | 78.78 | (0.17) | ||||||
| Tutku | 108 | 78.83 | (0.13) | ||||||
| Rauma | 17 | 79.15 | (0.33) | 0.003 | |||||
| Ever/never smoking | |||||||||
| Never | 304 | 84.0 | (0.13) | Never | - | - | - | ||
| Ever | 372 | 83.6 | (0.14) | 0.008 | Ever | 778 | 79.08 | (0.05) | NA |
| Pack-years of smoking | See males | ||||||||
| 1–20 | 120 | 83.6 | (0.25) | ||||||
| 21–40 | 116 | 83.3 | (0.27) | ||||||
| 41–60 | 77 | 83.3 | (0.30) | ||||||
| >60 | 53 | 83.2 | (0.35) | 0.20 | |||||
| Pack-years of smoking-males | |||||||||
| 1–20 | 106 | 84.2 | (0.20) | 1–20 | 187 | 79.00 | (0.10) | ||
| 21–40 | 107 | 84.1 | (0.20) | 21–40 | 339 | 79.10 | (0.08) | ||
| 41–60 | 72 | 84.2 | (0.25) | 41–60 | 197 | 79.13 | (0.10) | ||
| >60 | 50 | 83.8 | (0.30) | 0.05 | >60 | 55 | 79.02 | (0.19) | 0.60 |
| Pack-years of smoking-females | NA | ||||||||
| 1–20 | 14 | 83.6 | (0.68) | ||||||
| 21–40 | 9 | 82.3 | (0.86) | ||||||
| >40 | 8 | 82.1 | (0.91) | 0.16 | |||||
| Alcohol drinking (drinks per day) | (g per day) | ||||||||
| 0 | 119 | 83.8 | (0.19) | 0 | 67 | 79.01 | (0.17) | ||
| 0 ≤ 0.5 | 283 | 83.9 | (0.14) | >0–12.1 | 332 | 79.08 | (0.07) | ||
| >0.5 | 274 | 83.8 | (0.15) | 0.97 | >12.1 | 379 | 79.01 | (0.07) | 0.74 |
| Vegetable intake (servings per day) | |||||||||
| ≤5 | 335 | 83.8 | (0.13) | <749.5 | 415 | 79.06 | (0.06) | ||
| >5 | 341 | 83.9 | (0.13) | 0.83 | ≥749.5 | 363 | 79.10 | (0.08) | 0.71 |
| Fruit intake (servings per day) | |||||||||
| ≤3 | 342 | 83.7 | (0.13) | <233.1 | 459 | 79.09 | (0.06) | ||
| >3 | 334 | 84.0 | (0.13) | 0.09 | ≥233.1 | 319 | 79.05 | (0.08) | 0.71 |
| Folate (diet and supplement, mg per day) | |||||||||
| ≤539.2 | 338 | 83.8 | (0.13) | <346.1 | 401 | 79.1 | (0.07) | ||
| >539.2 | 338 | 83.9 | (0.13) | 0.66 | ≥346.1 | 377 | 79.06 | (0.08) | 0.65 |
| Vitamin B6 (diet and supplement, mg per day) | |||||||||
| ≤3.5 | 339 | 83.8 | (0.13) | <2.5 | 400 | 79.06 | (0.07) | ||
| >3.5 | 337 | 83.9 | (0.13) | 0.56 | ≥2.5 | 378 | 79.1 | (0.08) | 0.67 |
| Vitamin B12 (diet and supplement, mg per day) | |||||||||
| ≤9.1 | 341 | 83.8 | (0.13) | <11.0 | 421 | 79.15 | (0.06) | ||
| >9.1 | 335 | 83.9 | (0.13) | 0.54 | ≥11.0 | 357 | 78.97 | (0.08) | 0.08 |
| Dietary methionine(mg per day) | |||||||||
| ≤1.8 | 337 | 83.8 | (0.12) | <2.1 | 409 | 79.12 | (0.06) | ||
| >1.8 | 339 | 83.9 | (0.14) | 0.60 | ≥2.1 | 369 | 79.01 | (0.08) | 0.27 |
| Dietary protein (g per day) | |||||||||
| ≤83.5 | 338 | 83.9 | (0.12) | <94.8 | 410 | 79.1 | (0.06) | ||
| >83.5 | 338 | 83.8 | (0.14) | 0.91 | ≥94.8 | 368 | 79.05 | (0.08) | 0.62 |
N, number; NA, not applicable; SE, standard error; mg, micrograms; g, grams; dx, diagnosis; PLCO, Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Cohort. 1Adjusted for age at blood draw and sex (PLCO only). 2F-test for categorical variables and P-trend for ordinal variables.