. 2013 Dec 6;9(3):404–415. doi: 10.4161/epi.27386

Table 4. Odds ratios and 95% confidence intervals for bladder cancer risk and LINE-1%5mC by gender and smoking status in PLCO.

	NEVER SMOKER					EVER SMOKER
Gender	N Case	N Control	OR²	95% CI²	P²	N Case	N Control	OR²	95% CI²	P²
Male
Q1¹	13	49	REF	-	-	36	92	FER	-	-
Q2	12	49	0.91	0.36–2.28	0.84	50	82	1.77	1.02–3.10	0.04
Q3	15	63	0.92	0.40–2.13	0.84	62	88	2.03	1.18–3.50	0.01
Q4	13	58	0.79	0.33–1.91	0.60	41	79	1.64	0.91–2.94	0.10
P-trend					0.63					0.07
P-interaction										0.56
Q1	13	49	REF	-	-	36	92	REF	-	-
Q2–Q4	40	170	0.88	0.43–1.78	0.71	153	249	1.83	1.14–2.95	0.01
P-interaction										0.16
Female
Q1	7	22	1.00	-	-	12	15
Q2	2	18	0.35	0.06–1.91	0.23	5	2	1.43	0.21–9.98	0.72
Q3	7	23	0.95	0.29–3.14	0.93	12	6	2.55	0.57–11.46	0.22
Q4	6	22	0.84	0.24–2.91	0.78	6	8	1.06	0.25–4.47	0.94
P-trend					0.99					0.61
P-interaction										0.35
Q1	7	22	1.00	-	-	12	15	1.00	-	-
Q2-Q4	15	63	0.74	0.27–2.03	0.55	23	16	1.63	0.54–4.93	0.39
P-interaction										0.27

N, number; OR, odds ratio; CI, confidence interval; PLCO, Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. ¹Quartile cutpoints were based on sex-specific control distributions: PLCO males, 78.3: <82.9, <84.3, <85.7, ≤89.7%; females, 78.4: <82.7, <83.4, <84.9, ≤89.5%. ²Regression models adjusted for age at blood draw, packyears smoking, study center.