Figure 1B. Associations between air pollution and IFN-γ, and IL-6 DNA methylation across the 1st to 4th weeks of exposure (Estimates and associated 95% CI). *%5mC is the unit of DNA methylation and corresponds to the percentage of methylated cytosines over the sum of methylated and unmethylated cytosines at position 5. Variables included in the models: f₁(air pollutant), f₂(temperature), and f₃(relative humidity) represent the distributed-lag functions with sets of coefficients constrained by a natural spline (with 3 degrees of freedom) that correspond to the air pollution, temperature, and relative humidity associations at lags 0 and 27 days.