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. Author manuscript; available in PMC: 2015 Jun 10.
Published in final edited form as: Circulation. 2014 Apr 7;129(23):2403–2413. doi: 10.1161/CIRCULATIONAHA.113.007559

Figure 5.

Figure 5

Effect of D-PDMP on the expression of hepatic genes, which play roles in cholesterol and lipid metabolism. Expression of hepatic genes involved in LDL metabolism; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), Low density lipoprotein receptor (Ldlr), Sterol regulatory element binding transcription factor 1(Srebf1), Sterol regulatory element binding transcription factor 2(Srebf2) (A) HDL metabolism; apolipoprotein A-I(Apoa1), scavenger receptor class B (SRB-1), CD36 antigen (B) VLDL and Triglyceride metabolism; lipoprotein lipase (Lpl), very low density lipoprotein receptor (Vldlr) (C) and Cholesterol efflux and uptake; ATP-binding cassette sub-family ABCA1(Abca1), cholesterol 7 alpha-hydroxylase(Cyp7A1) (D) as assessed by quantitative real-time PCR. Expressions of these genes were significantly up regulated in mice treated with D-PDMP in a dose dependent manner. Values are means ± SEM. A nonparametric one-way ANOVA using the Kruskal-Wallis test and Dunn’s multiple comparison post-test were performed. * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001; n = 3.