Skip to main content
. Author manuscript; available in PMC: 2015 Jun 10.
Published in final edited form as: Circulation. 2014 Apr 7;129(23):2403ā€“2413. doi: 10.1161/CIRCULATIONAHA.113.007559

Figure 8.

Figure 8

D-PDMP inhibits ox-LDL induced LCS activity and atherosclerosis development. Oxidized LDL (ox-LDL) activates LacCer synthase (LCS) to produce large quantities of LacCer, which stimulates the activity of NADPH oxidase. Concomitantly, there is an increase in the generation of superoxide radicals (ROS). ROS mediates p44MAPK phosphorylation thereby stimulating c-fos expression, promoting cell proliferation of vascular-smooth-muscle cells further to angiogenesis and generation of atherosclerosis. D-PDMP, a potent inhibitor of LCS, impaired ox-LDL mediated induction of LCS activity thereby inhibiting the above pathway.