Appendix Table 2.

Estimated mean FDG ratio and tests for significant differences in FDG by age and APOE ε4 genotype from linear regression models, not partial volume corrected

ROI	Estimated mean FDG ratios^a				p-values for effect of:
ROI	Young carrier	Young noncarrier	Elderly carrier	Elderly noncarrier	Age p-value	APOE ε4 p-value	Age^a APOE ε4 p-value
Anterior cingulate	1.64	1.65	1.38	1.38	<0.001	0.62	0.96
Caudate	1.55	1.56	1.26	1.29	<0.001	0.27	0.21
Cingulate and/or precuneus	1.79	1.85	1.54	1.58	<0.001	0.07	0.63
Insula	1.56	1.56	1.28	1.28	<0.001	0.97	0.90
Lateral parietal	1.69	1.72	1.43	1.46	<0.001	0.13	0.97
Lateral temporal	1.56	1.56	1.35	1.37	<0.001	0.50	0.89
Medial temporal	1.24	1.22	1.11	1.11	<0.001	0.07	0.14
Occipital	1.70	1.73	1.53	1.55	<0.001	0.26	0.96
Orbito frontal	1.58	1.58	1.36	1.36	<0.001	0.88	0.98
Pallidum	1.37	1.33	1.40	1.40	<0.001	0.34	0.21
Paracentral lobule	1.55	1.61	1.47	1.48	<0.001	0.38	0.22
Postcentral gyrus	1.59	1.62	1.44	1.45	<0.001	0.68	0.66
Precentral gyrus	1.63	1.67	1.48	1.49	<0.001	0.50	0.40
Prefrontal	1.74	1.76	1.48	1.50	<0.001	0.49	0.84
Primary visual	1.94	1.96	1.64	1.66	<0.001	0.41	0.98
Putamen	1.83	1.82	1.62	1.63	<0.001	0.95	0.91
Rolandic operulum	1.68	1.67	1.40	1.41	<0.001	0.96	0.97
Supplementary motor area	1.70	1.74	1.50	1.52	<0.001	0.61	0.57
Thalamus	1.62	1.63	1.43	1.44	<0.001	0.69	0.79
AD signature meta-ROI	1.84	1.87	1.52	1.56	<0.001	0.04	0.92

Key: AD, Alzheimer’s disease; APOE, apolipoprotein E; FDG, ¹⁸F-fluorodeoxyglucose; ROI, region of interest.

Estimated FDG ratios for hypothetical participants based on regression model.