Table 2.
Serum biomarkers collected at enrollment; summaries presented as median (25th, 75th percentile) unless noted otherwise
| Reduced n = 1187 |
Preserved n = 94 |
Recovered n = 142 |
P* | |
|---|---|---|---|---|
| BNP, pg/mL | 214 (65, 681) | 77 (39, 234) | 66 (25, 159) | < 0.001 |
| PlGF, pg/mL | 18.8 (15.2, 23.1) | 18.5 (15.6, 22.5) | 18.4 (15.2, 22.3) | 0.86 |
| sFlt-1, pg/mL | 311 (261, 384) | 310 (267, 363) | 281 (247, 326) | < 0.001 |
| hsCRP, mg/L | 0.37 (0.15, 0.92) | 0.34 (0.15, 0.98) | 0.26 (0.11, 0.70) | 0.11 |
| MPO, pmol/L | 136 (94, 224) | 165 (106, 262) | 130 (94, 207) | 0.20 |
| ST2, ng/mL | 24.7 (19.8, 41.3) | 27.9 (21.5, 40.0) | 25.1 (18.2, 34.7) | 0.037 |
| TnI | < 0.001 | |||
| Detectable, n (%) | 810 (68) | 45 (48) | 63 (44) | |
| TnI, ng/mL, median (IQR)** | 0.020 (0.010, 0.040) | 0.010 (0.010, 0.030) | 0.010 (0.010, 0.020) | |
| Creatinine, mg/dL | 0.93 (0.77, 1.27) | 0.90 (0.77, 1.39) | 0.82 (0.72, 1.12) | 0.003 |
| Uric acid, mg/dL | 7.0 (5.7, 8.9) | 7.2 (5.5, 8.6) | 6.5 (5.1, 8.6) | 0.035 |
*
P values obtained from Kruskal-Wallis rank-sum tests
BNP, B-type natriuretic peptide; PlGF, placental growth factor; sFlt-1, soluble fms-like tyrosine kinase receptor-1; hsCRP, high-sensitivity C-reactive protein; MPO, myeloperoxidase; ST2, soluble toll-like receptor-2; TnI, troponin I