Table 2.

The proportion of neonates with seizures in the pre-cooling and cooling era groups stratified by encephalopathy severity.

	Cooling era	Pre-cooling era	Risk Ratio (95% CI)	p-value
All Neonates	n=151	n=73
Any Seizure (EEG or Clinical)	38%	64%	0.60 (0.46–0.78)	<0.001
Clinical Seizure†	27%	64%	0.42 (0.31–0.58)	<0.001
EEG-confirmed Seizure	27%	19%	1.42 (0.83–2.43)	0.2
Moderate Encephalopathy	n=120	n=61
Any Seizure (EEG or Clinical)	26%	61%	0.43 (0.30–0.61)	<0.001
Clinical Seizure†	17%	61%	0.27 (0.18–0.43)	<0.001
EEG-confirmed Seizure	18%	20%	0.93 (0.50–1.75)	0.8
Severe Encephalopathy	n=31	n=12
Any Seizure (EEG or Clinical)	87%	83%	1.05 (0.78–1.39)	0.8
Clinical Seizure†	68%	83%	0.81 (0.57–1.15)	0.3
EEG-confirmed Seizure	61%	17%	3.68 (1.01–13.44)	0.02

EEG, electroencephalogram

^†Any clinical seizure with or without EEG-confirmation.