Table 2.
Maternal serum 25(OH)D, nmol/L |
Cases (n) |
Unadjusted Incidencea |
Unadjusted risk difference (95% CI) |
Adjustedb risk difference (95% CI) |
Unadjusted risk ratio (95% CI) |
Adjustedb risk ratio (95% CI) |
---|---|---|---|---|---|---|
Preeclampsia (mild and severe) | ||||||
<30 | 185 | .028 | ref | ref | ref | ref |
30-<50 | 247 | .027 | −.0009 (−.006, .005) | .001 (−.003, .006) | .97 (.78, 1.2) | 1.1 (.84, 1.3) |
50-<75 | 171 | .022 | −.005 (−.011, −.0001) | −.002 (−.006, .003) | .79 (.63, .99) | .90 (.69, 1.2) |
≥75 | 114 | .026 | −.002 (−.008, .005) | .002 (−.004, .008) | .93 (.71, 1.2) | 1.1 (.89, 1.5) |
1-standard deviation c increase | −.002 (−.004, .0003) | .002 (−.015, .010) | .93 (.85, 1.0) | .99 (.89, 1.1) | ||
Mild preeclampsia | ||||||
<30 | 144 | .022 | ref | ref | ref | ref |
30-<50 | 179 | .020 | −.002 (−.006, .003) | 0 (−.003, .003) | .91 (.72, 1.2) | 1.0 (.77, 1.3) |
50-<75 | 137 | .018 | −.004 (−.009, .001) | −.001 (−.004, .002) | .80 (.62, 1.0) | .92 (.69, 1.2) |
≥75 | 100 | .023 | .001 (−.005, .007) | .003 (−.001, .007) | 1.0 (.79, 1.4) | 1.3 (.90, 1.7) |
1-standard deviation c increase | −.0004 (−.002, .001) | .003 (−.007, .012) | .98 (.89, 1.1) | 1.0 (.93, 1.2) | ||
Severe preeclampsia | ||||||
<30 | 41 | .0063 | ref | ref | ref | ref |
30-<50 | 68 | .0076 | .001 (−.002, .004) | .003 (−.002, .008) | 1.2 (.76, 1.7) | 1.3 (.86, 2.0) |
50-<75 | 34 | .0045 | −.002 (−.004, .001) | −.001 (−.006, .003) | .74 (.46, 1.2) | .87 (.87, 1.4) |
≥75 | 14 | .0032 | −.003 (−.006, −.0004) | −.003 (−.009, .003) | .51 (.27, .96) | .69 (.32, 1.4) |
1-standard deviation c increase | −.002 (−.003, −.0006) | −.002 (−.003, .0002) | .73 (.61, .90) | .79 (.62, .99) |
Incidence is based on the weighted sample.
Adjusted for maternal race, prepregnancy body mass index, parity, socioeconomic status, smoking status, latitude of study site, season of blood sampling, gestational age at blood sampling, and trimester of entry to prenatal care.
1 SD is 28 nmol/L.