Fig. 2.

Illustration of creatine role in rapid energy provision during skeletal muscle contraction. A reversible reaction catalyzed by creatine kinase transfers an N-phosphoryl group from phosphorylcreatine to adenosine diphosphate, regenerating adenosine triphosphate. Afterwards, phosphorylcreatine can be ressinthetized in mitochondria and transported to exert its role in adenosine triphosphate generation in citosol. Creatine kinase (CK), adenosine triphosphate (ATP), phosphocreatine (PCr), adenosine diphosphate (ADP)