Table 3.
Body weight changes and grade esophagitis prior and during (CT-)RT
| Retrospective | Prospective | ||
|---|---|---|---|
| Sequential CT-RT | Concurrent CT-RT | Concurrent CT-RT | |
| Weight loss diagnosis—start (CT-)RT (kg) | n = 83 | n = 94 | n = 6 |
| Mean ± SDa | −1.31 ± 10.78 | −0.50 ± 3.03 | −0.13 ± 1.97 |
| Number of patients losing weight (n (%)): | |||
| ≤ 0 % loss of total body weight | 51 (61.4 %)* | 75 (81.5 %)* | 4 (66.7 %) |
| 0–5 % loss of total body weight | 17 (20.5 %)* | 8 (8.7 %)* | 2 (33.3 %) |
| ≥ 5 % loss of total body weight | 15 (18.1 %)* | 9 (9.8 %)* | 0 (0.00 %) |
| Weight loss week 1 (CT-)RT (kg) | n = 68 | n = 91 | |
| Mean ± SDb | 0.38 ± 2.48 | 0.61 ± 1.69 | |
| Number of patients losing weight (n (%)): | |||
| ≤ 0 % loss of total body weight | 39 (57.4 %) | 42 (46.2 %) | |
| 0–5 % loss of total body weight | 26 (38.2 %) | 45 (49.5 %) | |
| ≥ 5 % loss of total body weight | 3 (4.4 %) | 4 (4.4 %) | |
| Weight loss week 2 (CT-)RTb (kg) | n = 71 | n = 94 | n = 9 |
| Mean ± SD | 0.36 ± 2.27* | 1.58 ± 2.2* | 2.53 ± 1.75† |
| Number of patients losing weight (n (%)): | |||
| ≤ 0 % loss of total body weight | 37 (52.1 %)* | 27 (28.7 %) | 1 (11.1 %) |
| 0–5 % loss of total body weight | 29 (40.8 %)* | 50 (53.2 %) | 6 (66.7 %) |
| ≥ 5 % loss of total body weight | 5 (7.0 %)* | 17 (18.1 %) | 2 (22.2 %) |
| Weight loss week 3 (CT-)RT (kg) | n = 65 | n = 87 | n = 9 |
| Mean ± SD | 0.54 ± 2.21* | 1.95 ± 2.67* | 4.07 ± 3.07† |
| Number of patients losing weight (n (%)): | |||
| ≤ 0 % loss of total body weight | 31(47.7 %)* | 23 (26.4 %)* | 1 (11.1 %) |
| 0–5 % loss of total body weight | 29 (44.6 %)* | 47 (54.0 %)* | 3 (33.3 %) |
| ≥ 5 % loss of total body weight | 5 (7.7 %)* | 17 (19.5 %)* | 5 (55.6 %) |
| Weight loss week 4 (CT-)RT (kg) | n = 29 | n = 71 | |
| Mean ± SD | 0.22 ± 2.02* | 2.56 ± 3.36* | |
| Number of patients losing weight (n (%)): | |||
| ≤ 0 % loss of total body weight | 17 (60.7 %)* | 17 (23.9 %)* | |
| 0–5 % loss of total body weight | 9 (32.1 %)* | 33 (46.5 %)* | |
| ≥ 5 % loss of total body weight | 2 (7.1 %)* | 21(29.6 %)* | |
| Weight loss week 5 (CT-)RT (kg) | n = 9 | ||
| Mean ± SD | 5.62 ± 2.43† | ||
| Number of patients losing weight (n (%)): | |||
| ≤ 0 % loss of total body weight | 2 (22.2 %) | ||
| 0–5 % loss of total body weight | 0 (0.00 %) | ||
| ≥ 5 % loss of total body weight | 7 (77.8 %) | ||
| Weight loss week 4 post (CT-)RT (kg) | n = 9 | ||
| Mean ± SD | 4.41 ± 3.11† | ||
| Number of patients losing weight (n (%)): | |||
| ≤ 0 % loss of total body weight | 1 (11.1 %) | ||
| 0–5 % loss of total body weight | 2 (22.2 %) | ||
| ≥ 5 % loss of total body weight | 6 (66.7 %) | ||
| Grade esophagitis week 1 RT (n (%)) | n = 74 | n = 86 | |
| < 2 | 73 (98.7 %) | 81 (94.2 %) | |
| ≥ 2 | 1 (1.4 %) | 5 (5.8 %) | |
| Grade esophagitis week 2 RT (n (%)) | n = 79 | n = 85 | n = 9 |
| < 2 | 71(89.9 %) | 77 (90.6 %) | 7 (77.8 %) |
| ≥ 2 | 8 (10.1 %) | 8 (9.4 %) | 2 (22.2 %) |
| Grade esophagitis week 3 RT (n (%)) | n = 72 | n = 81 | n = 9 |
| < 2 | 48 (66.6 %) | 53 (65.4 %) | 5 (55.6 %) |
| ≥ 2 | 24(33.3 %) | 28(34.5 %) | 4 (44.4 %) |
| Grade esophagitis week 4 RT (n (%)) | n = 31 | n = 66 | |
| < 2 | 22 (71.0 %) | 43 (65.2 %) | |
| ≥ 2 | 9 (29.0 %) | 23 (34.8 %) | |
| Grade esophagitis week 5 RT (n (%)) | n = 8 | ||
| < 2 | 2 (25 %) | ||
| ≥ 2 | 6 (75 %) | ||
| Grade esophagitis week 4 post RT (n (%)) | n = 12 | ||
| < 2 | 8 (88.9 %) | ||
| ≥ 2 | 1 (11.1 %) | ||
*P < 0.05 in retrospective study, comparison between sequential and concurrent treated patients (independent sample T test or Pearson chi-square test)
† P < 0.05 in prospective study, comparison between body weight at a specific time point compared to body weight at diagnosis (paired sample T test)
aMean ± standard deviation (SD)
bIn the retrospective cohort, body weight loss during (CT-)RT is depicted relative to body weight at start of (CT-)RT. In the prospective cohort, the body weight is depicted relative to diagnosis