Table 5.
Single marker (a) and haplotype-based (b) genetic associations with quantitative measure of cognition
| (a) Single marker genetic associations with cognition | ||||||
|---|---|---|---|---|---|---|
| Phenotype | Marker | Gene | BP location | Model | Slope | p value |
| Verbal IQ | rs9295626 | KIAA0319 | 24,587,339 | Allelic | 1.40 | 0.00041 |
| Verbal IQ | rs9295626 | KIAA0319 | 24,587,339 | Additive | 1.39 | 0.00043 |
| Verbal IQ | rs7763790 | KIAA0319 | 24,615,063 | Allelic | −1.40 | 0.00045 |
| Verbal IQ | rs7763790 | KIAA0319 | 24,615,063 | Additive | −1.38 | 0.00048 |
| Verbal IQ | rs6935076 | KIAA0319 | 24,644,322 | Allelic | 1.16 | 0.00049 |
| Verbal IQ | rs6935076 | KIAA0319 | 24,644,322 | Additive | 1.15 | 0.00052 |
| Verbal IQ | rs9348646 | FAM65B | 24,052,526 | Allelic | −1.14 | 0.00066 |
| Verbal IQ | rs9348646 | FAM65B | 24,052,526 | Additive | −1.14 | 0.00066 |
| Full scale IQ | rs2328791 | N/A | 23,736,848 | Allelic | −1.21 | 0.00066 |
| Full scale IQ | rs2328791 | N/A | 23,736,848 | Additive | −1.18 | 0.00075 |
| Full scale IQ | rs2328791 | N/A | 23,736,848 | Recessive | −3.36 | 0.00042 |
| (b) Haplotype-based genetic associations with cognition | |||||
|---|---|---|---|---|---|
| Markers | Haplotype | Gene | BP location | Slope | p value |
| rs2817201, rs9295626 | AT | KIAA0319 | 24,585,214, 24,587,339 | 1.42 | 0.000378 |
| rs10456309, rs4576240, rs17307478, rs9356939, rs7763790, rs6456621 | GGTCAC | KIAA0319 | 24,589,562, 24,596,478, 24,605,024 24,613,354, 24,615,063, 24,618,511 | −1.40 | 0.000569 |
| rs6456624, rs6935076, rs2038137, rs3756821, rs1883593, rs3212236 | AGATA | KIAA0319 | 24,639,223, 24,644,322, 24,645,943, 24,646,821, 24,647,191, 24,648,455 | 1.81 | 0.0000145* |
| rs3777663, rs3756814, rs6931809, rs6916186, rs6933328, rs17491647 | TGTGGA | ACOT13/C6orf62 | 24,700,235, 24,705,835, 24,706,770, 24,708,523, 24,710,920, 24,713,723 | −1.56 | 0.000742 |
* Genetic association survives correction for multiple testing