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. 2014 Apr 22;392(1):85–93. doi: 10.1007/s11010-014-2021-7

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© The Author(s) 2014

Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 4 — The Notch signaling pathway enhanced the proliferation and differentiation of OP-hBMSCs. Growth curves (a) and plate colony formation assay (b) of OP-hBMSCs illustrate improved vitality in response to Notch activation.* p < 0.05, compared to the control. A significant increase in Runx2, ALP, and Osterix is observed in NICD1 transgene positive OP-hBMSCs. * p < 0.05, compared to the control (c). ALP staining and Alizarin red staining demonstrated the elevated osteogenic differentiation and mineralization in response to Notch signaling (d)