Fig. 6.

Vascular lesions due to intravascular deoxyhaemoglobin can be detected using susceptibility-weighted imaging in EAE mice. (A) shows hypointense spots around the grey/white matter boundary and pia mater of the lumbar spinal cord seen in vivo (before perfusion) which disappear after perfusion (white arrows). (B) shows hypointense spots in the white matter tracts of the cerebellum observed in vivo (before perfusion) which disappear after perfusion (white arrows). Taken together, these data indicate that many hypointensities detected with susceptibility-weighted imaging in EAE mice are due to deoxyhaemoglobin in blood vessels.

(Adapted from Nathoo et al. (2013a).)