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. 2014 Jun 12;4:5266. doi: 10.1038/srep05266

Figure 4. Single Ion Images of Chemical Species decreased in ALS.

Figure 4

Multivariate statistics of ROI spectral data using SAM and PLS DA resulted in detection of multiple molecular species displaying ALS associated decrease in the grey matter. Only compounds observed in negative mode displayed a decrease in ALS spinal cord. (A) Here, a decrease throughout the whole grey matter (arrows) was observed for various triglycerides (TG (46:4), [M − H]− 769.6; TG (46:3), [M − H]− 771.6; TG (50:1), [M − H]− 831.7). (B) Similarly, an unidentified peak at m/z 446.3 was found decreased in both ventral horn and whole grey matter (arrows). In contrast, cholesterol (C27H45O, [M − H]− 385.3) and vitamin E (C29H49O2, [M − H]− 429.3) were found consistently decreased in the ventral horn of ALS spinal cord but not in the whole grey matter. Scale bar = 4 mm.