Table 1.
Description of DNA methylation data sets
| Set | Analysis | n | Tissue | Description | Mean age | Age range | Platform | Reference | Public availability |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Consensus | 92 | WB | Dutch controls from ALS study | 64 | 34-88 | Infin 27 k | Novel data | GSE41037 |
| 2 | Consensus | 273 | WB | Dutch controls from SZ study | 33 | 16-65 | Infin 27 k | Novel data | GSE41037 |
| 3 | Consensus | 293 | WB | Dutch cases, SZ | 34 | 17-86 | Infin 27 k | Novel data | GSE41037 |
| 4 | Consensus | 190 | WB | Type 1 diabetics | 44 | 24-74 | Infin 27 k | [15] | GSE20067 |
| 5 | Consensus | 87 | WB | Healthy older women | 63 | 49-74 | Infin 27 k | [14] | GSE20236 |
| 6 | Consensus | 261 | WB | Healthy postmenopausal women from UKOPS | 65 | 52-78 | Infin 27 k | [15,33] | GSE19711 |
| 7 | Consensus | 132 | FCTX | FCTX brain | 48 | 16-101 | Infin 27 k | [18] | GSE15745 |
| 8 | Consensus | 126 | TCTX | TCTX brain | 48 | 15-101 | Infin 27 k | [18] | GSE15745 |
| 9 | Consensus | 123 | PONS | PONS brain | 46 | 15-101 | Infin 27 k | [18] | GSE15745 |
| 10 | Consensus | 111 | CRBLM | CRBLM brain | 47 | 16-96 | Infin 27 k | [18] | GSE15745 |
| 11 | Validation | 94 | WB 450 k | Controls and SZ | 32 | 18-65 | Illumina 450 k | Novel data | GSE41169 |
| 12 | Validation | 24 | MSCs | MSCs | 50 | 21-85 | Infin 27 k | [34,35] | GSE26519+GSE17448 |
| 13 | Validation | 50 | CD14+CD4+ | CD4+ T-cells and CD14+ monocytes | 36 | 16-69 | Infin 27 k | [14] | GSE20242 |
| 14 | Validation | 398 | Leukocyte | Pediatric population | 10 | 3-17 | Infin 27 k | [24] | GSE27097 |
| 15 | Validation | 72 | Leukocyte | Healthy children | 5 | 1-16 | Illumina 450 k | [24] | GSE36064 |
| 16 | Validation | 108 | Prefrontal cortex | Healthy controls | 26 | -0.5-84 | Infin 27 k | [19] | BrainCloudMethyl |
Data sets 1 to 10 were used in the consensus network analysis while data sets 11 to 16 were used in the module validation (preservation) analysis. Our novel WB DNA methylation data sets (numbered 1 to 3 and 11) are composed of (n = 92 + 273 + 293 + 94) individuals. The study involved multiple tissues (blood, brain) and different populations (adults and healthy children). Note that the mean age (and age ranges) differ greatly across the studies. ALS, amyotrophic lateral sclerosis; CRBLM, cerebellum; FCTX, frontal cortex; MSC, mesenchymal stromal cell; PONS, caudal pons; SZ, schizophrenia; TCTX, temporal cortex; UKOPS, United Kingdom Ovarian Cancer Population Study; WB, whole blood.