Table 1.
In-cis miRNA families and family members
| miRNA family a | miRNA | MIMAT | Chromosomal location (hg19) | Mature sequence (5′-3′ direction) b | Aberration c |
|---|---|---|---|---|---|
| miR-148ab-3p/152 |
miR-148a-3p |
MIMAT0000243 |
7p15.2 |
UCAGUGCACUACAGAACUUUGU |
Hypermethylated/hypogain |
| |
miR-148b-3p |
MIMAT0000759 |
12q13.13 |
UCAGUGCAUCACAGAACUUUGU |
Gain |
| miR-17/17-5p/20ab/20b-5p/93/106ab/427/518a-3p/519d |
miR-106b-5p |
MIMAT0000680 |
7q22.1 |
UAAAGUGCUGACAGUGCAGAU |
Hypogain |
| |
miR-17-5p |
MIMAT0000070 |
13q31.3 |
CAAAGUGCUUACAGUGCAGGUAG |
Hypomethylated/hypogain |
| |
miR-20a-5p |
MIMAT0000075 |
13q31.3 |
UAAAGUGCUUAUAGUGCAGGUAG |
Hypomethylated/hypogain |
| miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 |
miR-130b-3p |
MIMAT0000691 |
22q11.21 |
CAGUGCAAUGAUGAAAGGGCAU |
Hypogain |
| |
miR-454-3p |
MIMAT0003885 |
17q22 |
UAGUGCAAUAUUGCUUAUAGGGU |
Hypogain |
| miR-30abcdef/30abe-5p/384-5p |
miR-30b-5p |
MIMAT0000420 |
8q24.22 |
UGUAAACAUCCUACACUCAGCU |
Gain |
| |
miR-30c-5p |
MIMAT0000244 |
6q13 |
UGUAAACAUCCUACACUCUCAGC |
Hypomethylated |
| |
miR-30d-5p |
MIMAT0000245 |
8q24.22 |
UGUAAACAUCCCCGACUGGAAG |
Gain/Hypogain |
| |
miR-30e-5p |
MIMAT0000692 |
1p34.2 |
UGUAAACAUCCUUGACUGGAAG |
Gain |
| miR-25/32/92abc/363/363-3p/367 |
miR-92a-3p |
MIMAT0000092 |
13q31.1 |
UAUUGCACUUGUCCCGGCCUGU |
Hypomethylated/hypogain |
| miR-92b-3p | MIMAT0003218 | 1q22 | UAUUGCACUCGUCCCGGCCUCC | Gain/Hypogain |
aFrom TargetScan (release 6.2) [2,33].
bFrom miRBase (release 18) [38]. Nucleotides in bold highlight the seed sequence.
cAccording to Wilcoxon rank-sum tests. Aberrations highlighted in bold indicate main aberration type. Hypogain, significant in tests grouping samples with hypomethylation and/or gain.