Table 3.

Assessment of inflammatory parameters before and after 24 h of aminophylline.

Variable	Baseline value	24-h value	p Value
SUBSET THAT HAD AN ELEVATED C-REACTIVE PROTEIN AT BASELINE (n = 19)
White blood cella	11.4 ± 2.0 (9.4 [7.5, 11.2])	10.9 ± 1.6 (10.0 [6.5, 12.8])	0.76
Glucoseb	125.6 ± 8.7 (119 [97, 145])	127.7 ± 7.9 (121 [106, 143])	0.99
IL-6c	156.1 ± 89.7 (27.0 [9.4, 172.0])	37.3 ± 13.9 (9.4 [4.3, 20.0])	<0.0001
IL-8c	199.7 ± 69.3 (89 [51, 141])	202.7 ± 98.1 (64 [34, 99])	0.05
IL-10c	211.5 ± 113.1 (40.0 [20.0, 58.0])	72.9 ± 34.6 (21.0 [14.0, 33.0])	0.001
TNF-alphac	15.4 ± 3.1 (12.0 [7.5, 17.0])	11.0 ± 1.6 (8.5 [6.8, 12.0])	0.26
SUBSET OF ABOVE COHORT THAT RECEIVED THE SAME OR LESS CONCOMITANT ANTI-INFLAMMATORY MEDICATIONS DURING THE 24 h AFTER THE START OF AMINOPHYLLINE (n = 16)
IL-6c	180.2 ± 105.9 (27.0 [12.7, 183.0])	42.4 ± 16.3 (7.6 [4.3, 56.5])	<0.0001
IL-8c	218.7 ± 81.7 (85.5 [49.5, 164.0])	225.4 ± 116.1 (61.0 [33.5, 157.0])	0.09
IL-10c	106.1 ± 53.5 (33.0 [16.5, 48.5])	78.7 ± 41.0 (17.0 [13.5, 30.0])	0.009
TNF-alphac	12.8 ± 2.5 (10.5 [6.8, 14.0])	10.8 ± 1.9 (8.0 [6.5, 12.0])	0.26

Both the mean plus/minus the standard error of the mean as well as the median (in parentheses) with the corresponding interquartile range [in brackets] are displayed for each value at each time point.

The p value was determined by the difference of the two values for each patient using the Wilcoxon Signed Rank test and was based on only the patients who had values recorded at both time points.

^a White blood cell count expressed in terms of 1000 cells/μL.

^b Blood glucose levels expressed in units of milligrams per deciliter.

^c Cytokine levels expressed in units of picograms per milliliter.