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. 2014 Jun 12;8:159. doi: 10.3389/fncel.2014.00159

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Copyright © 2014 Houot, Burkland, Tripathy and Daly.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of neural units exhibiting pulse tracking responses. (A) Peri-stimulus rasters and corresponding histograms (below) from a single unit in response to 10 repeats of 500 ms 20 Hz (top) and 25 Hz (bottom) pulse trains of undiluted K8. (B) Typical results of power spectral density analysis of spiking in response to pulsed (red) and continuous (blue) stimulation for a same unit. Inset dashed line highlights the 4 Hz window centered on the pulsing frequency; integrated power measures were based on area within boundary and under curve. (C) Example peri-stimulus rasters from two units (rows) in responses to 20 Hz pulse trains elicited by blank (left) or odor (right) stimuli (empty odor cartridges) from units that were found to track pulsed stimuli. Odors were K10 and A9 for top and bottom panels, respectively. These highlight that unitary pulse tracking can occur in response to blanks but not all pulse tracking units track blank stimuli. (D) Examples of non-pulse tracking responses to 20 Hz pulse trains from units that were found to track pulsed stimuli (as shown in A and statistically confirmed in (B) to at least one odor. We defined four non-pulse tracking response classes: temporally patterned but not pulse tracking (TP), spike suppression (–), tonic excitatory response (+) and non-responsive (NR). Classification of response type was based on both a statistical change in firing rate and PSD analysis (see methods). Inset gray bars represent the odor presentation. Y-axis indicates trial-sum spike rates in a 1 ms binning window. (E) Percentage of unit responses (Y-axis) by response type (X-axis; defined above) and pulsing frequency. Results based only on units exhibiting a significant pulse tracking response to at least one odor (N = 36).