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Cellular composition is a major source of variability in DNAm datasets in whole blood. Principal components (PCs) (A) 1 and (B) 2 of the 456,655 DNAm probes (y-axis) and the first PC of the empirical cell counts (x-axis) are highly correlated. The first PC of the DNAm data explains 10.9% of the variance, and the second explains 9.3% of the variance. Color indicates data source, which are described in Additional file 1.
