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. 2014 Jun 27;449(2):229–234. doi: 10.1016/j.bbrc.2014.05.012

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© 2014 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).

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Fig. 1 — (A) Oxidation with cholesterol oxidase (step 1), followed by derivatisation with the GP reagent (step 2) and fragmentation by mass spectrometry (MS²). The reactions are exemplified by 24S,25-epoxycholesterol. (B) Structure of 24S,25-epoxycholesterol its isomer 24-oxocholesterol and hydrolysis and methanolysis products after oxidation/derivatisation. (C) Structure of 3β,7α-dihydroxycholest-5-en-24S,25-epoxide and (D) 24S-hydroxycholesterol following oxidation/derivatisation.