Figure 2.

The size of the ESS is almost independent of data accumulation. (A) An accumulation curve of editing sites per strain (data derived from Danecek et al., whole brain samples). Strain datasets are sorted in ascending order of editing site amount (that is, the first strain contains the least number of editing sites, the second is the strain with the least additional editing sites, and so on). This result shows that addition of data does not lead to the addition of more conserved sites. (B-D) Visualization of sites per strain, ESS (B), random sites selected from all sites in the same proportion as the ESS (C), and all other sites (D). Editing signal is colored in yellow; sites with no data, that have, fewer than three reads are colored in gray, and sites with no evidence for editing are colored in blue. The heat-maps demonstrate a strong editing signal for conserved sites over all mice strains in contrast to the non-conserved sites.