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. 2014 Jan 7;15(1):R5. doi: 10.1186/gb-2014-15-1-r5

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Copyright © 2013 Pinto et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Most of the ESS sites are located in a coding region or adjacent to such a site. (A) Genomic location of evolutionarily conserved sites. (B) Frequency of non-synonymous editing alterations in exonic sites for both groups demonstrates enrichment of sites that cause amino acid change in the ESS compared to the control (all other sites, P <2 × 10^-11 calculated by Fisher’s exact test). (C-E) Secondary structure shows spatial proximity of coding and intron sites of GRIK2 (C), FLNA (D) and BLCAP (E) genes; editing sites are highlighted in orange and marked by an arrow.