Study	Reason for exclusion
Balanzat 2004	Overview of three existing trials
Bousquet 2007	Budesonide/formoterol for maintenance and relief in uncontrolled asthma vs. high-dose salmeterol/fluticasone
COMPASS	Different doses of Symbicort used for maintenance
COSMOS	Comparison with maintenance on Fluticasone/Salmeterol
D5890C00003	SiT compared to higher dose maintenance regimen on BDF and Budesonide
Ind 2002	Formoterol v Terbutaline as reliever
Jenkins 2007	budesonide/formoterol dose adjustment with FeNO (not used as reliever)
Jonkers 2006	Single dose study
Loukides 2005	SiT compared to separate inhalers for maintenance treatment and Formoterol relief
Lundborg 2006	Higher dose combination maintenance therapy but no ICS maintenance arm
Richter 2007	Formoterol not combination therapy as reliever
SMILE	No comparison with maintenance ICS arm
SOMA	No maintenance ICS arm
Tattersfield 2001	Formoterol v Terbutaline as reliever