Trial name or title	SYMPHONIE
Methods	A Comparison of Symbicort Single Inhaler and Conventional Best Practice for the Treatment of Persistent Asthma in Adolescents and Adults. A 26-Week, Randomised, Open, Parallel Group Multicentre Study. Estimated enrolment: 1000
Participants	Inclusion Criteria: Age 12 years and older Minimum of 3 months history of asthma, diagnosed according to the American Thoracic Society (ATS) definition. Prescribed inhaled GCS at a dose of 3400 μg/day and within the approved label for the relevant drug during the last 3 months prior to Visit 1. Exclusion Criteria: Use of any beta-blocking agent, including eye-drops, Use of oral GCS as maintenance treatment, A history of smoking 3 10 pack years (1 pack year = 1 pack (20 cigarettes) per day for one year or equivalent).
Interventions	A flexible dose of Symbicort compared with conventional stepwise treatment according to asthma treatment guidelines in patients with persistent asthma
Outcomes	Primary Outcome Measures: Time to first severe asthma exacerbation Secondary Outcome Measures: Number of asthma exacerbations, Mean use of as-needed medication, Prescribed asthma medication, Asthma Control Questionnaire, Satisfaction with Asthma Treatment Questionnaire, Safety: Serious Adverse Events and discontinuations due to adverse events
Starting date	Sept 2005
Contact information
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