Comparison 1.

Adults and Adolescents treated with Single Inhaler Therapy versus Current Best Practice

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Patients with exacerbations causing hospitalisation	5	5378	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.59 [0.24, 1.45]
2 Patients with exacerbations treated with oral steroids	4	4470	Odds Ratio (M-H, Fixed, 95% CI)	0.83 [0.66, 1.03]
3 Serious Adverse Events (fatal)	3	4281	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.95 [0.39, 9.67]
4 Serious Adverse Events (non-fatal)	3	4281	Odds Ratio (M-H, Fixed, 95% CI)	1.02 [0.68, 1.52]
5 Discontinuation due to Adverse Events	3	4281	Odds Ratio (M-H, Fixed, 95% CI)	2.92 [1.70, 5.01]
6 Patients with “severe” exacerbation (time to event)	3	4281	Hazard Ratio (Fixed, 95% CI)	0.96 [0.85, 1.07]
7 Change in PEF (% predicted)	1		Mean Difference (Fixed, 95% CI)	Subtotals only
8 Rescue Medication Use (puffs per day)	1		Mean Difference (Fixed, 95% CI)	Subtotals only
9 Quality of Life (Change in ACQ score)	2		Mean Difference (Fixed, 95% CI)	Totals not selected
10 ICS dose (micrograms per day)	3		Mean Difference (Fixed, 95% CI)	Totals not selected