Comparison 2.
Adults and Adolescents treated with Single Inhaler Therapy versus fixed dose ICS
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Patients with exacerbations causing hospitalisation | 3 | 4209 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.56 [0.28, 1.09] |
| 1.1 Single inhaler therapy versus higher dose ICS | 3 | 4209 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.56 [0.28, 1.09] |
| 2 Patients with exacerbations treated with oral steroids | 4 | 4280 | Odds Ratio (M-H, Fixed, 95% CI) | 0.54 [0.45, 0.64] |
| 2.1 Single inhaler therapy versus higher dose ICS | 3 | 4209 | Odds Ratio (M-H, Fixed, 95% CI) | 0.53 [0.44, 0.63] |
| 2.2 Single inhaler therapy versus same dose ICS | 1 | 71 | Odds Ratio (M-H, Fixed, 95% CI) | 1.42 [0.29, 6.86] |
| 3 Serious Adverse Events (fatal) | 3 | 4209 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.37 [0.05, 2.62] |
| 3.1 Single inhaler therapy versus higher dose ICS | 3 | 4209 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.37 [0.05, 2.62] |
| 4 Serious Adverse Events (non-fatal) | 3 | 4209 | Odds Ratio (M-H, Fixed, 95% CI) | 0.97 [0.73, 1.29] |
| 4.1 Single inhaler therapy versus higher dose ICS | 3 | 4209 | Odds Ratio (M-H, Fixed, 95% CI) | 0.97 [0.73, 1.29] |
| 5 Discontinuation due to Adverse Events | 2 | 2586 | Odds Ratio (M-H, Fixed, 95% CI) | 0.57 [0.35, 0.93] |
| 5.1 Single inhaler therapy versus higher dose ICS | 2 | 2586 | Odds Ratio (M-H, Fixed, 95% CI) | 0.57 [0.35, 0.93] |
| 6 Patients with “severe” exacerbation (time to event) | 2 | 2586 | Hazard Ratio (Fixed, 95% CI) | 0.59 [0.49, 0.70] |
| 6.1 Single inhaler therapy versus higher dose ICS | 2 | 2586 | Hazard Ratio (Fixed, 95% CI) | 0.59 [0.49, 0.70] |
| 7 PEF (Litres/min) | 3 | Mean Difference (Fixed, 95% CI) | 22.29 [17.62, 26.95] | |
| 7.1 Single inhaler therapy versus higher dose ICS | 3 | Mean Difference (Fixed, 95% CI) | 22.29 [17.62, 26.95] | |
| 8 FEV1 increase (Litres) | 3 | Mean Difference (Fixed, 95% CI) | 0.10 [0.07, 0.13] | |
| 8.1 Single inhaler therapy versus higher dose ICS | 2 | Mean Difference (Fixed, 95% CI) | 0.10 [0.08, 0.13] | |
| 8.2 Single inhaler therapy versus same dose ICS | 1 | Mean Difference (Fixed, 95% CI) | 0.01 [−0.19, 0.21] | |
| 9 Rescue Medication Use (puffs per day) | 3 | Mean Difference (Fixed, 95% CI) | −0.37 [−0.49, −0.25] | |
| 9.1 Single inhaler therapy versus higher dose ICS | 3 | Mean Difference (Fixed, 95% CI) | −0.37 [−0.49, −0.25] | |
| 10 Quality of Life (Fall in ACQ score) | 1 | Mean Difference (Fixed, 95% CI) | 0.15 [−0.46, 0.76] | |
| 10.1 Single inhaler therapy versus same dose ICS | 1 | Mean Difference (Fixed, 95% CI) | 0.15 [−0.46, 0.76] |