Table 2.

Changes in parameters measured at baseline, 1st- and 2nd follow-up visits.

Parameter	Baseline	1st Follow-up Visit (6 months ± 1)		2nd Follow-up Visit (12 months ± 2)
		p value to Baseline		p value to Baseline
All patients (n = 18; 11M, 7F)
FEV1 (L)	3.30 (±0.78)	3.34 (±0.72)	0.078	3.40 (±0.73)	0.005
FVC (L)	4.28 (±0.90)	4.34 (±0.86)	0.105	4.43 (±0.78)	0.006
FEF25-75% (L/sec.)	2.75 (±0.72)	3.00 (±0.54)	0.006	3.11 (±0.57)	0.001
ACQ	2.03 (±0.37)	1.60 (±0.24)	<0.001	1.47 (±0.20)	<0.001
PC20 (mg/mL) *	1.24 (0.49, 3.27)	1.20 (0.44, 4.23)	0.594	2.56 (0.5, 5.55)	0.003
Cigarettes/day	21.9 (±4.5)	1.9 (±2.9)	<0.001	1.7 (±2.1)	<0.001
Exacerbations	1.17 (±0.9)	0.87 (±0.7)	0.296	0.78 (±0.7)	0.153
Single Users (n = 10; 7M, 3F)
FEV1 (L)	3.42 (±0.84)	3.49 (±0.75)	0.779	3.51 (±0.75)	0.032
FVC (L)	4.35 (±0.96)	4.52 (±0.86)	0.161	4.51 (0.81)	0.059
FEF25-75% (L/sec.)	2.95 (±0.53)	3.17 (±0.39)	0.093	3.20 (±0.54)	0.047
ACQ	2.12 (±0.42)	1.69 (±0.29)	0.024	1.50 (±0.19)	<0.001
PC20 (mg/mL) *	1.10 (0.49, 2.07)	1.14 (0.44, 3.55)	0.463	2.06 (0.5, 5.55)	0.043
Cigarettes/day	21.6 (±3.9)	-	-	-	-
Exacerbations	1.20 (±0.8)	1.13 (±0.6)	0.831	1.10 (±0.7)	0.773
Dual Users (n = 8; 4M, 4F)
FEV1 (L)	3.16 (±0.73)	3.17 (±0.71)	0.062	3.26 (±0.72)	0.05
FVC (L)	4.19 (±0.88)	4.13 (±0.88)	0.352	4.32 (±0.78)	0.05
FEF25-75% (L/sec.)	2.49 (±0.88)	2.81 (±0.64)	0.028	3.01 (±0.62)	0.012
ACQ	1.93 (±0.29)	1.50 (±0.15)	0.004	1.43 (±0.21)	0.002
PC20 (mg/mL) *	1.40 (0.82, 3.27)	1.28 (0.72, 4.23)	0.893	3.17 (2.39, 4.09)	0.028
Cigarettes/day	22.4 (±5.3)	5.0 (±2.6)	<0.001	3.9 (±1.0)	<0.001
Exacerbations	1.13 (±1.0)	0.57 (±0.8)	0.257	0.38 (±0.5)	0.078

Notes: n—number; M—male; F—female; L –litres; %—percentage; L/sec.—litres per second; mg/mL—milligram per milliliter; Data expressed as mean (±standard deviation); *Data expressed as geometric mean (range).