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. 2013 Jul 31;14(7):R81. doi: 10.1186/gb-2013-14-7-r81

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Copyright © 2013 Dürnberger et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Low complexity and disordered regions. (a) Compared to an average human protein, the proteins found in the nucleic acid (NA) interactome contained more residues in low complexity regions (P < 1.7E-11, KS test), a bias similar to what was observed for the mRNA interactome. This bias is augmented for proteins in both interactomes as opposed to proteins in the nucleic acid interactome only (mRNA interactome subtracted), which are mostly non-sequence-specific DNA binders. (b) The same biases are observed for disordered regions. TF, transcription factor.