Table 4.

Number of unique and shared ageCGs/genes affiliated with genes expressed within tissues ^a

	Unique ageCGs/genesb		Shared ageCGs/genesc		P -valued
	Expressed	Non-expressed	Expressed	Non-expressed
Blood	13 (65.0)	7 (35.0)	8 (22.9)	27 (77.1)	0.003 *
Brain	16 (72.7)	6 (27.3)	27 (75.0)	9 (25.0)	0.766
Kidney	82 (78.8)	22 (21.2)	17 (56.7)	13 (43.3)	0.019
Muscle	84 (88.4)	11 (11.6)	11 (42.3)	15 (57.7)	3.40 × 10-6 *

^aExpressed genes, FPKM > 0.25; non-expressed genes, FPKM < 0.05. Parentheses indicate percentage of total in each CpG context category.

^bUnique ageCGs/genes had q < 0.05 from linear regression results in one tissue and q > 0.5 for the same affiliated gene in the other three tissues.

^cShared ageCGs/genes had q < 0.05 in all four tissues.

^dResulting P-values from Fisher’s exact tests between the number of unique and shared, expressed or non-expressed ageCGs/genes within tissues.

*Significant P-values meet Bonferroni correction for multiple testing.