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Pharmacokinetics of ibuprofen and its glucuronides in hUGT1 mice and regular mice. Pharmacokinetics of ibuprofen (A) and ibuprofen acyl-glucuronides (B) in regular mice (closed circles) and hUGT1 mice (open circles) treated with ibuprofen (200 mg/kg, p.o.) are shown. Results are shown as means ± S.D. of the plasma concentration of ibuprofen or ibuprofen acyl-glucuronides (in micromoles) (n ≥ 3).
