Fig. 1.
The rate of current decline induced by photolysis of CNV-NLX (5 µM) increased after desensitization induced by ME (30 µM). (A) Two experiments, one where photolysis of CNV-NLX was applied at the peak of the ME-induced current and the second 10 minutes after the application of ME. Examples of the change in current induced by CNV-NLX at the peak (left) and 10 minutes after the application of ME (right) are shown. (B) Summarized results showing the time constant of decay at the peak (blue), after ME (10 minutes, green), and at the peak of a nonsaturating concentration of ME (1 µM, black).