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. 2014 Jul;86(1):52–61. doi: 10.1124/mol.114.092098

Fig. 3.

Fig. 3.

Application of DERM (1 µM) after desensitization with SST and OFQ does not change the rate of current decline induced by CNV-NLX. (A) Example trace of an experiment in which the current induced by SST (1 µM, 10 minutes) peaked and decayed, followed by the application of DERM and photolysis of CNV-NLX. (B) Dot plot of experiments measuring the time constant of current decay induced by CNV-NLX at the peak of the current induced by DERM (1 µM) in the presence of somatostatin (DERM + SST), OFQ (DERM + OFQ) and after the washout of OFQ (DERM wash OFQ). Shaded areas are the same as in Fig. 2, illustrating the standard error of experiments with DERM alone at the peak (top) and after 10 minutes (bottom). *P < 0.05 by one-way ANOVA compared with DERM alone; Dunnett post hoc. ns, not significant.