Fig. 8.

MOR desensitization does not change the noradrenaline activation of GIRK. (A) Example trace showing the current induced by photolysis of noradrenaline (arrows) during the application of DERM (1 µM) and DERM + naloxone (1 µM). (B) Summarized results showing the NA current decreased in DERM through occlusion, the reversal with naloxone (1 µM), the increase induced by cocaine (10 µM), followed by the inhibition with idazoxan (1 µM). (C) Superimposed traces of the current induced by caged noradrenaline (NA) before, 7–10 minutes in DERM, and after reversal with naloxone (1 µM). At bottom is the summarized rate of rise of the noradrenaline-induced current. Statistics tested with an analysis of variance, Dunnett’s post hoc test.