TABLE 3.

Identification of differentially expressed genes in CCLA-treated L. monocytogenes 08-5923^a

Gene name and function	Gene annotation	Product	Fold change
Cell division
clpE	lmo0997	ATP-dependent protease	+3.69
ftsW	lmo1071	Cell division protein FtsW	−2.14
divIVA	lmo2020	Cell division initiation protein	−2.01
rodA	lmo2428	Similar to cell division protein RodA	−2.64
ftsX	lmo2506	Cell division transport system permease protein	−2.08
ftsE	lmo2507	Cell division transport system ATP-binding protein	−2.32
mbl	lmo2525	Rod shape-determining protein MreB	−2.03
Cell wall synthesis
pdp	lmo0835	Peptidoglycan binding protein	−2.21
murE	lmo2038	UDP-N-acetylmuramoylalanyl-d-glutamate-2,6-diaminopimelate ligase	−2.02
murZ	lmo2552	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	−2.41
dacB2	lmo1855	d-Alanyl-d-alanine carboxypeptidase	−2.41
Membrane functions
abc	lmo0767	ABC transporter, permease protein	+2.13
mfs	lmo1250	Major facilitator superfamily	+2.05
ywzB	lmo2527	Similar to B. subtilis YwzB protein	+2.37
mptAB	lmo0096	PTS system, mannose-specific IIA and IIB component	+2.14
mptC	lmo0097	PTS system, mannose-specific IIC component	−2.29
celA	lmo2765	PTS system, cellobiose-specific IIA component	+2.35
celB	lmo2762	PTS system, cellobiose-specific IIB component	+2.10
celC	lmo2763	PTS system, cellobiose-specific IIC component	+2.81
Gene regulation
deoR	lmo2107	Similar to deoR family transcriptional regulator	+2.28
hrcA	lmo1475	Heat-inducible transcription repressor	+2.43
agrB	lmo0048	Similar to Staphylococcus two-component sensor histidine kinase AgrB	+3.18
Nucleotide and protein synthesis
fmt	lmo1823	Methionyl-tRNA formyltransferase	−2.07
hisC	lmo1925	Histidinol-phosphate aminotransferase	−2.26
gidA	lmo2810	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA	−2.61
Metabolism
tgl	lmo0717	Transglycosylase	−2.01
baiE	lmo0754	Bile acid 7-alpha dehydratase	−2.74
trn	lmo1903	Thioredoxin	−2.21
yitT	lmo1909	YitT family protein	−2.05
malP	lmo2121	Maltose phosphorylase	+2.01
bglK	lmo2764	Beta-glucoside kinase	+2.85
Motility
flgD	lmo0696	Flagellar basal body rod modification protein	−2.70
fliF	lmo0713	Flagellar MS-ring protein	−2.20
motB	lmo0686	Chemotaxis protein	−2.23
fliM	lmo0699	Flagellar motor switch protein	−2.26
cheA	lmo0692	Two-component sensor histidine kinase	−2.82
Unknown
lmo0867	lmo0867	Hypothetical protein	−2.39
lmo1796	lmo1796	Hypothetical protein	−2.33
lmo2311	lmo2311	Hypothetical protein	+2.25
lmo2317	lmo2317	Hypothetical protein	+2.07

^aIdentification of differentially expressed genes in CCLA-treated (4 h) L. monocytogenes 08-5923 is represented as fold change (n = 3; P < 0.05). +, upregulation; −, downregulation.