Table 2.
Psychopathological and neuropsychological data.
| HDP (n = 18) | HDP–CTR (n = 18) | HDP vs. CTR | HDR (n = 19) | HDR–CTR (n = 18) | HDR vs. CTR | |
|---|---|---|---|---|---|---|
| Intellectual level | 89.1 (8.4) | 90.2 (11.4) | NS | 89.5 (11.1) | 92.9 (8.6) | NS |
| HDFCS | 11.8 (1.5) | |||||
| BDI-II | 11.7 (8.4) | 4.3 (2.0) | 0.001 | 4.05 (3.0) | 4.2 (1.6) | NS |
| HAM-A | 7.2 (3.3) | 1.8 (1.2) | 0.00 | 3.3 (1.6) | 1.5 (1.2) | 0.003 |
| MOCA total score | 24.9 (2.6) | 27.7 (1.4) | 0.003 | 27.7 (1.4) | 29.2 (1.2) | 0.001 |
| IFS total score | 19.6 (4.6) | 23.6 (1.5) | 0.001 | 23.9 (1.9) | 26.0 (2.0) | 0.003 |
| Motor series | 2.5 (0.7) | 2.8 (0.3) | NS | 2.8 (0.3) | 3.0 (0.0) | NS |
| Conflicting instructions | 2.1 (1.1) | 2.8 (0.3) | 0.01 | 2.8 (0.3) | 2.9 (0.2) | NS |
| Go–no go | 1.7 (1.0) | 2.6 (0.6) | 0.006 | 2.6 (0.5) | 2.7 (0.4) | NS |
| Backward digits span | 2.9 (0.8) | 3.1 (0.7) | NS | 3.2 (0.8) | 4.0 (1.1) | 0.01 |
| Verbal working memory | 1.7 (0.5) | 2.0 (0.0) | 0.04 | 2.0 (0.0) | 1.9 (0.2) | NS |
| Spatial working memory | 1.3 (1.3) | 2.0 (0.5) | NS | 2.1 (0.6) | 3.1 (0.8) | 0.003 |
| Abstraction capacity | 2.1 (0.9) | 2.6 (0.4) | 0.03 | 2.6 (0.4) | 2.6 (0.4) | NS |
| Verbal inhibitory control | 5.1 (1.3) | 5.5 (0.7) | NS | 5.5 (0.7) | 5.4 (0.9) | NS |
| Stroop test (W) | 65.3 (24.5) | 84.0 (15.3) | 0.01 | 84.3 (14.9) | 91.8 (7.9) | NS |
| Stroop test (C) | 48.0 (23.5) | 63.0 (10.4) | 0.01 | 62.6 (10.2) | 62.9 (12.5) | NS |
| Stroop test (W/C) | 24.6 (17.8) | 31.7 (12.1) | NS | 31.5 (11.8) | 38.7 (14.2) | NS |
| Similarities subtest | 18.0 (2.7) | 18.2 (4.4) | NS | 18.1 (4.3) | 19.3 (3.2) | NS |
It represents the overall results for all groups.
HDP, Huntington’s disease patients; HDR, relatives; UHDRS, Unified Huntington’s Disease Rating Scale; HDFCS, Total Functional Capacity Scale; BDI-II, Beck Depression Inventory-II; HAM-A, Hamilton Anxiety Rating Scale; IFS, INECO frontal screening; W, word; C, color, W/C, word/color.