TABLE 3.
Serum neutralizing antibody responses in ferrets following one or two doses of AH13 ca vaccine
| Test antigen | Serum neutralizing antibody GMT in ferrets immunized with the AH13 ca vaccinea |
|||||
|---|---|---|---|---|---|---|
| 1 dose |
2 dosesb |
|||||
| Day 14 | Day 28 | Day 14 | Day 28 | Day 42 | Day 56 | |
| AH13 (H7N9) wt | 30 | 220 | 22 | 63 | 281 | 294 |
| NL03 (H7N7) wt | 11 | 63 | 11 | 16 | 99 | 87 |
a
Ferrets (n = 8) were inoculated i.n. with one or two doses of 107 FFU of the AH13 ca vaccine. Serum was collected at the indicated days after the first immunization and assessed by the microneutralization assay. Antibodies were not detected in preimmunization sera and in sera from mock-immunized ferrets.
b
Ferrets received 2 doses of vaccine administered 28 days apart.