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Phylogenetic analysis (neighbor-joining tree with Tamura-Nei parameter [43]; gamma distribution = 3.71; 1,000 bootstrap replicates) of the open reading frames of different BVDV strains. Recent highly virulent isolates form a distinct subcluster within genotype 2c (highlighted in bold). Strain BVDV-2a 890 clusters within genotype 2a (highlighted in bold italics). Bootstrap values of >50 are indicated at the branches.
