FIG 6.
Viral loads in the respiratory tract and nervous system tissues of WT H7N1- and ferret-adapted ACp11-infected ferrets. Six ferrets were inoculated with 1 × 105 TCID50 of either WT H7N1 or ACp11 H7N1 (virus stock generated from p11 AC 3). Tissue samples were collected from the large and small intestines, kidneys, spleen, liver, lungs, trachea, nasal turbinates, brain, and olfactory bulb. Tissue samples were titrated and normalized to the weight of input tissue. No virus was isolated from the intestines, kidneys, spleen, or liver. Each bar represents the viral load of an individual ferret. Viral titers are shown for upper respiratory tract tissue (nasal turbinates and trachea) (A), the lower respiratory tract or lungs (B), and nervous system tissue (olfactory bulb and brain) (C).